It will take approximately twelve strikes of the sap near Lazarevic to ultimately do him in. This area is fairly wide open, and multi-tiered, so the idea is going to no doubt be to work your way in a circular motion, drawing your enemy all around, and detonating the sap when he's nearby. The second thing to keep in mind is to keep your gun reloaded at all times, and to collect ammunition as you move around. By constantly moving, you can avoid most of these attacks. Lazarevic's shotgun is a powerful weapon indeed, and in addition to shooting it off with incredible accuracy (even from a distance), he'll also pepper you with multiple grenades at once, and even get into melee fights with you (if this happens, follow the on-screen prompt to escape with your life). The first is that you'll want to keep moving, and other than to turn around and shoot some sap, you'll never want to stop moving. Now, there are a few things worth noting. This is how you're going to take this guy down. By luring your enemy into areas with this sap and then detonating the sap by shooting it with a single bullet, you will be able to damage Lazarevic enough that it's worth your time doing. There's only one answer here, and that's all of that blue sap hanging off of various trees and other objects in your vicinity. Likewise, even though you'll find plenty of grenades to use here, you'll want to stray away from them. While you can strike him with your bullets and manage to do some damage, it's not worth trying to do this, because it's simply not going to work well enough. Because he's so buffed out on the Tree of Life's sap, normal fire isn't going to do much damage to him. Fighting Lazarevic is, in premise, quite simple. Lazarevic then pulls out his shotgun, and with a frightening smirk on his face, the game's final battle begins in earnest.ДЄnd now, the battle. Taking the damage like a sponge, his men respond in kind, shooting their assault rifles in Drake's direction. After calling him out, Drake shows himself and quickly lets a few rounds fly towards Lazarevic's chest. And with it, he somehow senses that Drake is in the area watching him. Since Lazarevic did indeed absorb the Tree of Life's sap, he's not only healed himself but gained that aforementioned power. It appears that this substance has some sort of curative affect in addition to the power it grants anyone who absorbs it. This causes all of those scars, burns and bruises all over his body to disappear. Staying hidden, Drake observes Lazarevic take some of the blue substance from the pool, which he subsequently drinks without any hesitation. Nate moves forward towards the pool of resin and sap that's at the source of the Tree of Life's power, but it's too late, as Lazarevic and his men are already there. When you reach the base of the Tree of Life, a cutscene will take over once more.

Uncharted 2 chapter 25